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ChemInform Abstract: The Formation of 2-Hydroxy-4-hydroxymethyl-3-(indol-3-yl)-cyclopent-2-enone Derivatives from Ascorbigens.

✍ Scribed by Alexander M. Korolev; Larisa N. Yudina; Ilyia I. Rozhkov; Ludmila N. Lysenkova; Eduard I. Lazhko; Yury N. Luzikov; Maria N. Preobrazhenskaya


Publisher
John Wiley and Sons
Year
2010
Weight
35 KB
Volume
32
Category
Article
ISSN
0931-7597

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✦ Synopsis


Abstract

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Synthesis of 5-[(Indol-2-on-3-yl)methyl]-2,2-dimethyl-1,3-dioxane-4,6diones and Spirocyclopropyloxindole Derivatives. Potential Aldose Reductase Inhibitors. -Indoles (I) are transformed into indolyl derivatives (IV) following a literature process. Subsequent reaction with 1 equiv. of NBS generates