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ChemInform Abstract: The Discovery of Acylated β-Amino Acids as Potent and Orally Bioavailable VLA-4 Antagonists.

✍ Scribed by Linus S. Lin; et al. et al.

Publisher
John Wiley and Sons
Year
2010
Weight
29 KB
Volume
33
Category
Article
ISSN
0931-7597

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## Abstract Structure‐activity relationship studies lead to the discovery of compound (I), which shows potent ACAT inhibitory activity (IC~50~ = 12 nM) and good pharmacokinetic profile in mice.