Glucosamine was readily transformed into N-di-glycosyl donors β(1-4)and β(1-3)-linked disaccharides 13 and 15a-c, respectively. From 18 as galactosyl donor and 14a methylmaleoyl (DMM) protected derivative 1 which furnished trichloroacetimidate 4 as glycosyl donor. Reaction as acceptor β(1-3)-linked
✦ LIBER ✦
ChemInform Abstract: The Dimethylmaleoyl Group as Amino Protective Group — Application to the Synthesis of Glucosamine-Containing Oligosaccharides.
✍ Scribed by M. R. E. ALY; J. C. CASTRO-PALOMINO; E.-S. I. IBRAHIM; E.-S. H. EL-ASHRY; R. R. SCHMIDT
- Publisher
- John Wiley and Sons
- Year
- 2010
- Weight
- 25 KB
- Volume
- 30
- Category
- Article
- ISSN
- 0931-7597
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The N-DMM-Protected lactosamine derivative 2 was readily neohexaose). Glycosylation of acceptor 10 with donor 4 furnished tetrasaccharide 16 which, employing standard transformed into the corresponding glycosyl donor 4 and into acceptor 5. A TMSOTf-catalyzed glycosidation afforded the procedures, ga