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ChemInform Abstract: tert-Butylsulfonyl (Bus), a New Protecting Group for Amines.

โœ Scribed by P. SUN; S. M. WEINREB; M. SHANG

Publisher
John Wiley and Sons
Year
2010
Weight
34 KB
Volume
29
Category
Article
ISSN
0931-7597

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โœฆ Synopsis

tert-Butylsulfonyl (Bus), a New Protecting Group for Amines.

tert-Butylsulfonyl is found to be an efficient protecting group for primary and secondary amines. It is stable to strong bases and metalation conditions and can be easily removed by mild acidic solvolysis. Interestingly, secondary sulfonamides can be selectively cleaved in the presence of primary ones. -

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