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ChemInform Abstract: Synthesis Studies Directed Towards Epothilone A: Enantioselective Synthesis of a C7—C15 Carboxaldehyde Segment.

✍ Scribed by P. BIJOY; M. A. AVERY

Publisher
John Wiley and Sons
Year
2010
Weight
34 KB
Volume
29
Category
Article
ISSN
0931-7597

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✦ Synopsis

Synthesis Studies Directed Towards Epothilone A: Enantioselective Synthesis of a C 7 -C 15 Carboxaldehyde Segment.

-Based on the diastereoselective alkylation of Oppolzer's sultam (III) with the iodide (II), the desired (S)-product (IV) is prepared and readily transformed to the C7-C15 segment of epothilone A.

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ChemInform Abstract: Chiral Synthesis of the C3-13 Segment of Epothilone A.
✍ Z.-Y. LIU; C.-Z. YU; J.-D. YANG 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 32 KB

Chiral Synthesis of the C 3-13 Segment of Epothilone A. -Epothilones represent a new class of macrolides showing all the biological effects of taxol, but their structure is totally different. On route to an epothilone A synthesis, the preparation of the C 3 -C 13 segment (V) from inexpensive gerani