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ChemInform Abstract: Synthesis of the Isomers of (1R)-3-(Phenylthio)tropane-2-carboxylic Acid Methyl Ester. A New Class of Ligands for the Dopamine Transporter.

✍ Scribed by M. THIRUVAZHI; P. ABRAHAM; M. J. KUHAR; F. I. CARROLL

Publisher: John Wiley and Sons
Year: 2010
Weight: 31 KB
Volume: 28
Category: Article
ISSN: 0931-7597
DOI: 10.1002/chin.199733194

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✦ Synopsis

Synthesis of the Isomers of (1R)-3-(Phenylthio)tropane-2-carboxylic Acid Methyl Ester. A New Class of Ligands for the Dopamine Transporter.

-The syntheses of all four diastereomers of the title compound is described. The isomer (IV) is the most potent at the cocaine binding site of the dopamine transporter. -(THIRUVAZHI, M.; ABRAHAM,

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