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ChemInform Abstract: Synthesis of Taxoids. Part 5. Synthesis and Evaluation of Novel Water-Soluble Prodrugs of a 3′-Desphenyl-3′-cyclopropyl Analogue of Docetaxel.

✍ Scribed by Tetsuo Yamaguchi; Naoyuki Harada; Kunihiko Ozaki; Hiroaki Arakawa; Kouji Oda; Noriyuki Nakanishi; Kenji Tsujihara; Tomiki Hashiyama


Publisher
John Wiley and Sons
Year
2010
Weight
37 KB
Volume
30
Category
Article
ISSN
0931-7597

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ChemInform Abstract: Synthesis and Evalu
✍ K. UOTO; H. TAKENOSHITA; T. YOSHINO; Y. HIROTA; S. ANDO; I. MITSUI; H. TERASAWA; 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 32 KB

Synthesis and Evaluation of Water-Soluble Non-Prodrug Analogues of Docetaxel Bearing sec-Aminoethyl Group at the C-10 Position. -Some of the newly synthesized analogues, e.g. (II), exhibit cytotoxicity comparable or superior to that of docetaxel. In addition, the corresponding mesylates show a high