ChemInform Abstract: Synthesis and Evaluation of Water-Soluble Non-Prodrug Analogues of Docetaxel Bearing sec-Aminoethyl Group at the C-10 Position.

✍ Scribed by K. UOTO; H. TAKENOSHITA; T. YOSHINO; Y. HIROTA; S. ANDO; I. MITSUI; H. TERASAWA; T. SOGA

• Publisher: John Wiley and Sons
• Year: 2010
• Weight: 32 KB
• Volume: 29
• Category: Article
• ISSN: 0931-7597
• DOI: 10.1002/chin.199847205

✦ Synopsis

Synthesis and Evaluation of Water-Soluble Non-Prodrug Analogues of Docetaxel Bearing sec-Aminoethyl Group at the C-10 Position.

-Some of the newly synthesized analogues, e.g. (II), exhibit cytotoxicity comparable or superior to that of docetaxel. In addition, the corresponding mesylates show a high water-solubility. -(UOTO, K.