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ChemInform Abstract: Synthesis of Pyridopyrimidone Derivatives and Their Activity Against P. falciparum in vitro.

✍ Scribed by J. DOMINGUEZ; J. CHARRIS; L. IARRUSSO; S. LOPEZ; G. LOBO; F. RIGGIONE

Publisher
John Wiley and Sons
Year
2010
Weight
27 KB
Volume
28
Category
Article
ISSN
0931-7597

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✦ Synopsis

Synthesis of Pyridopyrimidone Derivatives and Their Activity Against P. falciparum in vitro. -The title compounds (II) and (IV) are synthesized as potential antimalarial agents on the basis of the pharmacological properties of existing quinolone analogues. Among these compounds only derivative ( IIb) exhibits significant antimalarial activity. -(DOMINGUEZ,

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