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ChemInform Abstract: Synthesis of Oligonucleotides Containing 2′-Azido- and 2′-Amino-2′- deoxyuridine Using Phosphotriester Chemistry.

✍ Scribed by N. N. POLUSHIN; I. P. SMIRNOV; A. N. VERENTCHIKOV; J. M. COULL

Book ID: 112036068
Publisher: John Wiley and Sons
Year: 2010
Weight: 25 KB
Volume: 27
Category: Article
ISSN: 0931-7597
DOI: 10.1002/chin.199633238

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Synthesis and Biological Activity of Bis(pivaloyloxymethyl) Ester of 2'-Azido-2'-deoxyuridine 5'-Monophosphate. -The title compound (III) which is the membrane-permeable prodrug of the phosphate (I), is evaluated with positive results for inhibition of cell growth with 60 tumor cell lines.