ChemInform Abstract: Synthesis of N-Alkoxycarbonyl-3-substituted Tetramic Acids and Functionalized Enols via C-Acylation Reactions of Active Methylene Compounds with N-Hydroxysuccinimide Esters of N-Alkoxycarbonyl-α-amino Acids.

✍ Scribed by A. DETSI; M. MICHA-SCRETTAS; O. IGGLESSI-MARKOPOULOU

• Publisher: John Wiley and Sons
• Year: 2010
• Weight: 36 KB
• Volume: 29
• Category: Article
• ISSN: 0931-7597
• DOI: 10.1002/chin.199849140

✦ Synopsis

Synthesis of N-Alkoxycarbonyl-3-substituted Tetramic Acids and Functionalized Enols via C-Acylation Reactions of Active Methylene Compounds with N-Hydroxysuccinimide Esters of N-Alkoxycarbonylα-amino Acids.

-A new, mild, and advantageous approach is used for the preparation of the title compounds, e.g. (III). Partial racemization occurs in the case of optically active compounds, c.f. (VI). -(DETSI, A.