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ChemInform Abstract: Synthesis of N-Acetylglucosaminyl and Diacetylchitobiosyl Amides of Heterocyclic Carboxylic Acids as Potential Chitinase Inhibitors.

✍ Scribed by Antje Rottmann; Bjoernar Synstad; Vincent Eijsink; Martin G. Peter

Publisher
John Wiley and Sons
Year
2010
Weight
28 KB
Volume
30
Category
Article
ISSN
0931-7597

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✦ Synopsis

Synthesis of N-Acetylglucosaminyl and Diacetylchitobiosyl Amides of Heterocyclic Carboxylic Acids as Potential Chitinase Inhibitors.

-A series of new compounds are synthesized, consisting of a 1-acylamino-2acetamido-1,2-dideoxy-Ξ²-D-glucose unit, where the 1-N-acyl group is derived from a heterocyclic carboxylic acid. Enzyme assays show that these compounds are moderate inhibitors of chitinases. -(ROTTMANN, ANTJE; SYNSTAD,

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