ChemInform Abstract: Synthesis of 2-Substituted 4-Quinazolone-5-carboxylic Acids as Inhibitors of DNA-Gyrase.
β Scribed by Z. SUI; V. N. NGUYEN; J. FERNANDEZ; J. F. BARRETT; K. A. OHEMENG
- Publisher
- John Wiley and Sons
- Year
- 2010
- Weight
- 29 KB
- Volume
- 28
- Category
- Article
- ISSN
- 0931-7597
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Synthesis of Substituted Benzoyl Acrylic Acids as Potential Inhibitors of Phospholipase A 2 . -Acylation of long-chain alkylbenzenes with maleic anhydride derivatives under Friedel-Crafts conditions provides access to benzoylacrylic acids [cf. (III)/(IV), (VIII)], which are evaluated for their abili