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ChemInform Abstract: Synthesis of Methyl 4-Acetamido-N-acetyl-4-deoxy-α- and β-4- epi-neuraminic Acids.

✍ Scribed by B. P. BANDGAR; S. V. PATIL; E. ZBIRAL


Book ID
112028370
Publisher
John Wiley and Sons
Year
2010
Weight
31 KB
Volume
27
Category
Article
ISSN
0931-7597

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N-Acetylneuraminic acid (1) can be transformed into the methyl a-u-ketoside 2 which, by reaction with methanesulfonyl chloride, yields the corresponding 4-0 mesylate 3 and the 4.7-di-0 -mesylate 4 as a by-product. Compound 3 reacts with Nal giving the 4-dcoxy-4-iodo compound 5 with cquatorial orient