ChemInform Abstract: Synthesis of Homochiral Amino Acid Pyridazine and Pyrrole Analogues of Glutamate Antagonists.
β Scribed by Andrew Dinsmore; Paul M. Doyle; Matthias Steger; Douglas W. Young
- Publisher
- John Wiley and Sons
- Year
- 2010
- Weight
- 35 KB
- Volume
- 33
- Category
- Article
- ISSN
- 0931-7597
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Synthesis and Biological Activity of Cyclic Analogues of MPPG and MCPG as Metabotropic Glutamate Receptor Antagonists. -The synthesis of the two rigidified phenylglycine analogues (VII) and ( XI) is described. Key step is the application of the Bucherer-Bergs reaction affording the hydantoins (VI)