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ChemInform Abstract: Synthesis of Homochiral Amino Acid Pyridazine and Pyrrole Analogues of Glutamate Antagonists.

✍ Scribed by Andrew Dinsmore; Paul M. Doyle; Matthias Steger; Douglas W. Young


Publisher
John Wiley and Sons
Year
2010
Weight
35 KB
Volume
33
Category
Article
ISSN
0931-7597

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Synthesis and Biological Activity of Cyclic Analogues of MPPG and MCPG as Metabotropic Glutamate Receptor Antagonists. -The synthesis of the two rigidified phenylglycine analogues (VII) and ( XI) is described. Key step is the application of the Bucherer-Bergs reaction affording the hydantoins (VI)