ChemInform Abstract: Synthesis of Functionalized 2,5-Ethano-2-benzazepines
β Scribed by V. M. Kisel'; V. A. Kovtunenko
- Publisher
- John Wiley and Sons
- Year
- 2010
- Weight
- 25 KB
- Volume
- 31
- Category
- Article
- ISSN
- 0931-7597
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Chemistry of Functionalized Benzazepines. Part 5. Synthesis and Chemical Transformation of the 1,2,4,5-Tetrahydrospiro[3H-2benzazepine-3,1'-cycloalkanes]. -A number of new spiroderivatives of tetrahydro-2-benzazepine (III) are synthesized by reaction of imines (I) with allyl Grignard reagent (II)
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## Synthesis of . -In continuation of a research on biologically active spiroheterocycles, a synthesis of the spirobenzazepine (VIII) is desired. The compound is obtained by a route involving Heck-type cyclization of the monoprotected amine (I) and the formation of the seven-membered ring (VII)