ChemInform Abstract: Synthesis of Spiro[benzazepine-2,4′-piperidine].

✍ Scribed by J. COSSY; C. POITEVIN; D. GOMEZ PARDO; J.-L. PEGLION; A. DESSINGES

• Publisher: John Wiley and Sons
• Year: 2010
• Weight: 33 KB
• Volume: 29
• Category: Article
• ISSN: 0931-7597
• DOI: 10.1002/chin.199846182

✦ Synopsis

Synthesis of

.

-In continuation of a research on biologically active spiroheterocycles, a synthesis of the spirobenzazepine (VIII) is desired. The compound is obtained by a route involving Heck-type cyclization of the monoprotected amine (I) and the formation of the seven-membered ring (VII) by aldol condensation. -(COSSY,