Synthesis and Some Transformations of 2-Acetamido-5-amino-3,4,6-tri-O-benzyl-2,5-dideoxy-D-glucono-1,5-lactam. -The synthesis and transformations of the title compound (IV), a useful precursor of N-acetylglucosaminidase inhibitors, are presented. -(GRANIER, T.;
ChemInform Abstract: Synthesis of Four Stereoisomers of 5-Amino-2,5-dideoxy-heptono-1,5-lactams.
โ Scribed by F. DEGIORGIS; M. LOMBARDO; C. TROMBINI
- Publisher
- John Wiley and Sons
- Year
- 2010
- Weight
- 35 KB
- Volume
- 29
- Category
- Article
- ISSN
- 0931-7597
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โฆ Synopsis
Synthesis of Four Stereoisomers of 5-Amino-2,5-dideoxy-heptono-1,5-lactams.
-The synthesis of title compounds like (VII) and (VIII) is achieved via addition of the nitrone (I) to the furan (II) yielding tetrahydrofuroisoxazolones. The stereochemical outcome depends on kind and amount of the Lewis acid used.
๐ SIMILAR VOLUMES
Synthesis of 2',5'-Dideoxy-5'-Substituted Pyrimidine Nucleosides via Intramolecular Glycosylation. -5'-Azido and 5'-arylthio-5-deoxypyrimidine nucleosides are synthesized employing intramolecular glycosylation, in which a reaction intermediate is treated in situ with an azide salt or thiol. In some