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ChemInform Abstract: Synthesis of Benzothiophene Analogues of Ketoconazole and Itraconazole.

✍ Scribed by J. BOLOS; S. GUBERT; L. ANGLADA; A. SACRISTAN; J. A. ORTIZ

Publisher
John Wiley and Sons
Year
2010
Weight
38 KB
Volume
29
Category
Article
ISSN
0931-7597

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✦ Synopsis

Synthesis of Benzothiophene Analogues of Ketoconazole and Itraconazole.

-Benzothiophene analogues (VII) and (XV) of the orally active antifungal title agents are synthesized and subjected to preliminary pharmacological evaluation. The key heterocyclic system (III) is prepared by formation of the enamine between benzothiophene (I) and piperazine (II). -(BOLOS,

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