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ChemInform Abstract: Synthesis of Apoptolidinone (I).

โœ Scribed by Julia Schuppan; Hermut Wehlan; Sonja Keiper; Ulrich Koert


Publisher
John Wiley and Sons
Year
2010
Weight
25 KB
Volume
32
Category
Article
ISSN
0931-7597

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A Cu -mediated coupling of the northern and southern units and a ring-size selective macrolactonization are the key steps in the convergent, first total synthesis of apoptolidinone, the aglycon of the potential antitumor compound apoptolidin. (The wavey lines in the picture are the retrosynthetic di

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