Synthesis of Apoptolidinone
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Julia Schuppan; Hermut Wehlan; Sonja Keiper; Ulrich Koert
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Article
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2001
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John Wiley and Sons
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English
โ 102 KB
A Cu -mediated coupling of the northern and southern units and a ring-size selective macrolactonization are the key steps in the convergent, first total synthesis of apoptolidinone, the aglycon of the potential antitumor compound apoptolidin. (The wavey lines in the picture are the retrosynthetic di