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ChemInform Abstract: Synthesis of A-Ring Fragments of 1α,25-Dihydroxyvitamin D3 and Taxane Diterpenoids: Effective Construction of Conjugated Formylcyclohexene Frameworks from Isoxazolines.

✍ Scribed by T. ISHIKAWA; S. IKEDA; M. IBE; S. SAITO

Publisher
John Wiley and Sons
Year
2010
Weight
44 KB
Volume
29
Category
Article
ISSN
0931-7597

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✦ Synopsis

Synthesis of A-Ring Fragments of 1α,25-Dihydroxyvitamin D 3 and Taxane Diterpenoids: Effective Construction of Conjugated Formylcyclohexene Frameworks from Isoxazolines.

-The key step in the novel syntheses of the A-ring fragments of 1α,25-dihydroxyvitamin D 3 and taxane diterpenoids is intramolecular cycloaddition of the oximes (II) and (XI) followed by reductive hydrolysis of the isoxazoline ring. -(ISHIKAWA, T.;

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Copper-Mediated Alkylation of Vitamin D C-Ring. Synthesis of C11-Functionalized 1α,25-Dihydroxyvitamin D3. -The functionalization of C-11 of CD-ring fragments of vitamin D3, e.g. (I), with organocopper reagents is studied. The application results in an efficient, convergent synthesis of the calcitr