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ChemInform Abstract: Synthesis of a Fluorogenic Cyclooctyne Activated by Cu-Free Click Chemistry.

✍ Scribed by John C. Jewett; Carolyn R. Bertozzi


Publisher
John Wiley and Sons
Year
2012
Weight
39 KB
Volume
43
Category
Article
ISSN
0931-7597

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## Abstract We report the regioselective Cu‐free click modification of styrene functionalized DNA with nitrile oxides. A series of modified oligodeoxynucleotides (nine base pairs) was prepared with increasing styrene density. 1,3‐Dipolar cycloaddition with nitrile oxides allows the high density fun