## Synthesis of a Hybrid Analogue of the Esperamicin and Dynemicin Cores. -The compound (VI) represents an enediyne analogue hybrid of the core structures of esperamicin and dynemicin. Key step in the sequence is the intramolecular Reissert-type reaction of the anion of the Z-1,3-diyn-2-ene (III)
ChemInform Abstract: Synthesis of a Dynemicin A Analogue Without the Nitrogen.
β Scribed by Andre J. Niestroj; Clemens Bruhn; Martin E. Maier
- Publisher
- John Wiley and Sons
- Year
- 2010
- Weight
- 27 KB
- Volume
- 30
- Category
- Article
- ISSN
- 0931-7597
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A New Synthesis of Carmethizole and Related Nitrogen Analogues. -Short and efficient routes for the synthesis of carmethizole (V), a novel bis-carbamate alkylating agent, and the related nitrogen analogue (VII) are described. Key step is the selective derivatization of the 4,5-disubstituted imidazo