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ChemInform Abstract: Synthesis of 8-Hydroxyquinolines with Amino and Thioalkyl Functionalities at Position 4.

✍ Scribed by Walaa A. E. Omar; Juha P. Heiskanen; Osmo E. O. Hormi

Publisher: John Wiley and Sons
Year: 2008
Weight: 31 KB
Volume: 39
Category: Article
ISSN: 0931-7597
DOI: 10.1002/chin.200830145

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## Abstract magnified image Six 8‐hydroxyquinolines with amino and thioalkyl functionalities at position 4 have been prepared. The synthesis starts with chlorination of the readily available 4‐hydroxy‐8‐tosyloxyquinoline to give 4‐chloro‐8‐tosyloxyquinoline in 94% yield. Treatment of the 4‐chloro‐

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