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ChemInform Abstract: Synthesis of 6α-Methyl-16α,17α- cyclohexanoprogesterone via γ-Methylenation of 16α,17. alpha.-Cyclohexanopregn-4-ene-3,20-dione.

✍ Scribed by I. S. LEVINA; A. V. KAMERNITSKII

Publisher: John Wiley and Sons
Year: 2010
Weight: 31 KB
Volume: 28
Category: Article
ISSN: 0931-7597
DOI: 10.1002/chin.199748235

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✦ Synopsis

Synthesis of 6α-Methyl-16α,17α-cyclohexanoprogesterone via γ-Methylenation of 16α,17. alpha.-Cyclohexanopregn-4-ene-3,20-dione.

-An improved synthetic way to the title cyclohexanoprogesterone (IV) is presented. The introduction of the 6α-methyl group is achieved by regioselective γ-methylenation of the δ4-3-oxopentarane (I) with diethoxymethane and subsequent hydrogenation of the double bond.

-(LEVINA, I. S.;

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