ChemInform Abstract: Synthesis of 5-(2-Amino-2-deoxy-β-D-glucopyranosyloxymethyl)-2′-deoxyuridine and Its Incorporation into Oligothymidylates.
✍ Scribed by Juerg Hunziker
- Publisher
- John Wiley and Sons
- Year
- 2010
- Weight
- 38 KB
- Volume
- 30
- Category
- Article
- ISSN
- 0931-7597
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A High-Yield Synthesis of Deoxy-2-fluoroinosine and Its Incorporation into Oligonucleotides. -Diazotization of the deoxyguanosine derivative (I) followed by mild fluorination and selective O-silyl deprotection under the conditions shown provides an improved synthesis of the title nucleoside. It is