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ChemInform Abstract: Synthesis of 3-C-Hydroxymethyl- and 3-Deoxyisofagomine and Investigation of Their Binding to β-Glucosidase.

✍ Scribed by Henrik H. Jensen; Anders Lohse; Bent O. Petersen; Jens Oe. Duus; Mikael Bols

Publisher
John Wiley and Sons
Year
2010
Weight
33 KB
Volume
31
Category
Article
ISSN
0931-7597

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Synthesis and Antiviral Evaluation of 4'-Hydroxymethyl-2',3'dideoxy-3' -thianucleosides and Their Cyclic Monophosphates. -The title compounds (VII) and (VIII) are evaluated for anti-HIV activity. The described approach includes the first reported use of phosphorodiamidites for the preparation of nu