Synthesis of CMI-977, a Potent 5-Lipoxygenase Inhibitor. -A facile large-scale synthesis of the potent 5-lipoxygenase inhibitor CMI-977 (XI) in enantiomerically pure form starting from hydroxymethyl-Ξ³-butyrolactone (I) derived from (S)-glutamic acid is described (yields given in g). -(CAI,
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ChemInform Abstract: Synthesis of (2S,5S)-5-Fluoromethylornithine; a Potent Inhibitor of Ornithine Aminotransferase.
β Scribed by J. B. DUCEP; B. HEINTZELMANN; K. JUND; B. LESUR; M. SCHLEIMER; P. R. ZIMMERMANN
- Publisher
- John Wiley and Sons
- Year
- 2010
- Weight
- 31 KB
- Volume
- 28
- Category
- Article
- ISSN
- 0931-7597
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β¦ Synopsis
Abstract
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