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ChemInform Abstract: Synthesis of 24ξ-Squalamine, an Antiinfective Steroidal Polyamine.

✍ Scribed by A. D. PECHULIS; F. H. III BELLEVUE; C. L. CIOFFI; S. G. TRAPP; J. P. FOJTIK; A. A. MCKITTY; W. A. KINNEY; L. L. FRYE

Book ID
112023854
Publisher
John Wiley and Sons
Year
2010
Weight
34 KB
Volume
26
Category
Article
ISSN
0931-7597

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Macrocyclic Polyamine Lactam Synthesis by Diphenyl Ether Closure of 23-, 24-and 28-Membered Rings. -The first synthesis of 23-, 24-, and 28-membered ring polyamine lactam conjugates (IV), (VII), and (VIII), which are nitro-substituted analogues of cadabicine class alkaloids, proceeds via the proced