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ChemInform Abstract: Synthesis of 2-Chloro-2′-5′-dideoxy-5′- difluoromethylphosphinyladenosine (XI): A Nonhydrolyzable Isosteric, Isopolar Analogue of 2-Chlorodeoxyadenosine Monophosphate.

✍ Scribed by S. G. LEVY; D. B. WASSON; D. A. CARSON; H. B. COTTAM

Book ID
112040846
Publisher
John Wiley and Sons
Year
2010
Weight
34 KB
Volume
27
Category
Article
ISSN
0931-7597

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ChemInform Abstract: Synthesis and Biolo
ChemInform Abstract: Synthesis and Biological Activity of Bis(pivaloyloxymethyl) Ester of 2′-Azido-2′-deoxyuridine 5′-Monophosphate.
✍ S. H. KANG; A. K. SINHABABU; M. J. CHO 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 28 KB 👁 1 views

Synthesis and Biological Activity of Bis(pivaloyloxymethyl) Ester of 2'-Azido-2'-deoxyuridine 5'-Monophosphate. -The title compound (III) which is the membrane-permeable prodrug of the phosphate (I), is evaluated with positive results for inhibition of cell growth with 60 tumor cell lines.