Synthesis of 1β-Methylcarbapenem Antibio
✍
Jean-Christophe Galland; Sylvain Roland; Joël Malpart; Monique Savignac; Jean-Pi
📂
Article
📅
1999
🏛
John Wiley and Sons
🌐
English
⚖ 302 KB
An efficient diastereoselective multi-step synthesis of in the hydrogenation step to control the β-stereochemistry at the 1-position, and a π-allylpalladium ring-closure strategy is bicyclic 1β-methylcarbapenem antibiotic precursors has been developed, starting from the commercially available 4-used