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ChemInform Abstract: Synthesis of 1β-Methylcarbapenem Antibiotic Precursors by Cyclization Using π-Allylpalladium Complexes.

✍ Scribed by Jean-Christophe Galland; Sylvain Roland; Joel Malpart; Monique Savignac; Jean-Pierre Genet


Publisher
John Wiley and Sons
Year
2010
Weight
36 KB
Volume
30
Category
Article
ISSN
0931-7597

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Synthesis of 1β-Methylcarbapenem Antibio
✍ Jean-Christophe Galland; Sylvain Roland; Joël Malpart; Monique Savignac; Jean-Pi 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 English ⚖ 302 KB

An efficient diastereoselective multi-step synthesis of in the hydrogenation step to control the β-stereochemistry at the 1-position, and a π-allylpalladium ring-closure strategy is bicyclic 1β-methylcarbapenem antibiotic precursors has been developed, starting from the commercially available 4-used