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ChemInform Abstract: Synthesis of 1,5-Diarylpyrazol-3-propanoic Acids Towards Inhibition of Cyclooxygenase-1/2 Activity and 5-Lipoxygenase-Mediated LTB4 Formation.

โœ Scribed by Burcu Caliskan Erguen; Maria Teresa Nunez; Luis Labeaga; Francisco Ledo; Janice Darlington; Gretchen Bain; Bilge Cakir; Erden Banoglu


Publisher
John Wiley and Sons
Year
2010
Weight
27 KB
Volume
41
Category
Article
ISSN
0931-7597

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ChemInform Abstract: Synthesis and Biolo
โœ T. D. PENNING; J. J. TALLAY; S. R. BERTENSHAW; J. S. CARTER; P. W. COLLINS; S. D ๐Ÿ“‚ Article ๐Ÿ“… 2010 ๐Ÿ› John Wiley and Sons โš– 35 KB ๐Ÿ‘ 1 views

Synthesis and Biological Evaluation of the 1,5-Diarylpyrazole Class of Cyclooxygenase-2 Inhibitors: Identification of 4-(5-(4-Methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)benzenesulfonamide (SC-58635, Celecoxib). -Claisen condensation, followed by regioselective reaction with the hydrochloride