ChemInform Abstract: Synthesis of 1,2,5,6-Tetrahydro-3-pyridinylalanine: A Key Intermediate in the Preparation of Thrombin Inhibitor UK-239,326.
β Scribed by Paul V. Fish; Alan D. Brown; John C. Danilewicz; David Ellis; J. David Hardstone; Keith James
- Publisher
- John Wiley and Sons
- Year
- 2009
- Weight
- 38 KB
- Volume
- 40
- Category
- Article
- ISSN
- 0931-7597
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The Use of Zinc Enolates in the Synthesis of a Key Intermediate for the Preparation of Trinem Antibiotics. -The reaction of the azetidinone (I) with zinc enolates derived from a chiral methoxycyclohexanone provides the trinem antibiotic key intermediate (III) with good diastereoselectivity. -(KENNE