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ChemInform Abstract: Synthesis of 1-O-(2′,3′-Dihydroxypropyl)-5-deoxy-β-D- ribofuranosides with (CH3)2As, (CH3)2As=S or (CH3)3As+ Groups as Substituents at the 5-Position.

✍ Scribed by J. LIU; D. H. O'BRIEN; K. J. IRGOLIC

Book ID
112032802
Publisher
John Wiley and Sons
Year
2010
Weight
33 KB
Volume
27
Category
Article
ISSN
0931-7597

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Synthesis of 1-O-(2′,3′-dihydroxypropyl)
Synthesis of 1-O-(2′,3′-dihydroxypropyl)5-deoxy-β-D-ribofuranosides with (CH3)2As, (CH3)2AsS or (CH3)3As+ groups as substituents at the 5-position
✍ Jinggao Liu; Daniel H. O'Brien; Kurt J. Irgolic 📂 Article 📅 1996 🏛 John Wiley and Sons 🌐 English ⚖ 796 KB

Eight arsenic-containing ribosides were prepared from dimethyl( 1 -0-methyl1 -5-deoxy-2,3-0-isopropylidene-P-D-ribofuranos-5-yl)arsine and (2's)- Reactions of the arsines with sulfur produced the compounds with a (CH,),As=S group as substituent in the 5-position. Treatment of these dimethyl(ribosy1

Synthesis of 1-O-R-5-deoxy-β-D-ribofuran
Synthesis of 1-O-R-5-deoxy-β-D-ribofuranosides with (CH3)2As and (CH3)2AsO as substituents at the 5-position and a methyl or 2′,3′-dihydroxypropyl group as the aglycone in the 1-position
✍ Jinggao Liu; Daniel H. O'Brien; Kurt J. Irgolic 📂 Article 📅 1996 🏛 John Wiley and Sons 🌐 English ⚖ 896 KB

including the naturally occurring (2'R)dimethyl[ l-O-(2',3'-dihydroxypropyl)-5-deoxy-~-~-ribofuranos-5-yl]arsine oxide, were prepared in multi-step reactions from D-ribose and tetramethyldiarsine. The synthetic procedure uses the early substitution of the hydroxy group with bromine at C5, subsequent