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ChemInform Abstract: Synthesis, in vitro Biological Stability, and Anti-HIV Activity of 5- Halo (or Methoxy)-6-alkoxy (Azido or Hydroxy)-5,6-dihydro-2′,3′- didehydro-3′-deoxythymidine Diastereomers as Potential Prodrugs of 2′, 3′-Didehydro-3′-deoxythymidine (D4T).

✍ Scribed by R. KUMAR; L. WANG; L. I. WIEBE; E. E. KNAUS

Book ID: 112033420
Publisher: John Wiley and Sons
Year: 2010
Weight: 36 KB
Volume: 27
Category: Article
ISSN: 0931-7597
DOI: 10.1002/chin.199625227

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Synthesis, in vitro anti-HIV Activity, and Biological Stability of 5'-O-Myristoyl Analogue Derivatives of 3'-Fluoro-2',3'-dideoxythymidine (FLT) as Potential Bifunctional Prodrugs of FLT. -Among several derivatives of the highly active FLT (Ia), the analogues (Ib) and (Ie) are found to be the most e