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ChemInform Abstract: Synthesis, Antiinflammatory and Analgesic Activity of 2-Oxo-1,2,5,6,7,8-hexahydroquinoline-4-carboxylic Acid Amides.

โœ Scribed by T. A. Smirnova; M. Yu. Gavrilov; M. V. Vasilyuk; A. S. Zaks; M. E. Kon'shin

Publisher
John Wiley and Sons
Year
2010
Weight
30 KB
Volume
30
Category
Article
ISSN
0931-7597

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โœฆ Synopsis

Synthesis, Antiinflammatory and Analgesic Activity of 2-Oxo-1,2,5,6,7,8-hexahydroquinoline-4-carboxylic Acid Amides.

-Reaction of hexahydroquinoline-4-carboxylic acid (I) with amines in alkaline solution affords the title amides (III) as possible new biologically active compounds which easily undergo methylation at the exocyclic nitrogen atom. Compounds (IIIa) and (IIId) possess antiinflammatory activity and p-bromophenyl derivative (IIIe) shows weak analgesic activity. -(SMIRNOVA, T. A.; GAVRILOV,

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