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ChemInform Abstract: Synthesis and Selective M-Cholinoblocking Activity of Tetraamines (VI). Part 1.

โœ Scribed by A. YA. BESPALOV; T. L. GORCHAKOVA; V. V. DOLGO-SABUROV; V. I. ZLOBINA; A. B. KOSMACHEV; S. G. KUZNETSOV; N. M. LIBMAN; A. V. LYCHAKOV; N. P. PODOSINOVIKOVA; S. M. RAMSH; S. A. SHELKOVNIKOV

Publisher
John Wiley and Sons
Year
2010
Weight
30 KB
Volume
28
Category
Article
ISSN
0931-7597

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ChemInform Abstract: Synthesis and ฮฑ1-Antagonist Activity of New Prazosin- and Benextramine-Related Tetraamine Disulfides.
โœ D. GIARDINA; M. CRUCIANELLI; U. GULINI; G. MARUCCI; C. MELCHIORRE; S. SPAMPINATO ๐Ÿ“‚ Article ๐Ÿ“… 2010 ๐Ÿ› John Wiley and Sons โš– 30 KB

Synthesis and ฮฑ1-Antagonist Activity of New Prazosin-and Benextramine-Related Tetraamine Disulfides. -The title compounds of type (I), prepared by standard procedures, display marked selectivity at ฮฑ1-adrenoceptors. In contrast to prazosin and benextramine (I) shows an 11-fold selectivity for ฮฑ 1B-a