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ChemInform Abstract: Synthesis and Protein Binding of (4-Carboxybutyl)carbamoyl-substituted Taxoids.

โœ Scribed by Torsten Blitzke; Alexander Baranovsky; Bernd Schneider

Publisher
John Wiley and Sons
Year
2010
Weight
27 KB
Volume
32
Category
Article
ISSN
0931-7597

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Synthesis and Protein Binding of (4-Carb
Synthesis and Protein Binding of (4-Carboxybutyl)carbamoyl- Substituted Taxoids
โœ Torsten Blitzke; Alexander Baranovsky; Bernd Schneider ๐Ÿ“‚ Article ๐Ÿ“… 2001 ๐Ÿ› John Wiley and Sons ๐ŸŒ German โš– 91 KB

4-Carboxybutyl)carbamates 5 and 6, as well as 10, derived from 10-O-deacetylbaccatin III (1) and paclitaxel (2), respectively, were synthesized by reaction of unprotected 1 and 2'-O-(methoxyacetyl)paclitaxel (8), respectively, with trimethylsilyl 5-isocyanatopentanoate in good yields. The carbamoyl-