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ChemInform Abstract: Synthesis and Phototoxic Property of Tetra- and Octa-Glycoconjugated Tetraphenylchlorins.

โœ Scribed by Yuji Mikata; Yoko Onchi; Minako Shibata; Toyoji Kakuchi; Hiroshi Ono; Shun-ichiro Ogura; Ichiro Okura; Shigenobu Yano


Publisher
John Wiley and Sons
Year
2010
Weight
27 KB
Volume
30
Category
Article
ISSN
0931-7597

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โœฆ Synopsis


Synthesis and Phototoxic Property of Tetra-and Octa-Glycoconjugated Tetraphenylchlorins.

-The title compounds such as (I) are prepared via a diimine reduction of the peracetylated sugar porphyrin derivatives with subsequent deprotection. The physicochemical properties of these compounds are examined and the usefulness for a photodynamic therapy is discussed.


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Synthesis, Characterization and Photocytotoxicity of a Glycoconjugated meso-Monoarylbenzochlorin. -The title compound (I) is prepared efficiently from meso monoaryl porphyrin and 3-(dimethylamino)acrolein by a regiospecific Vilsmeier reaction followed by cyclization and glycosylation. It shows good