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ChemInform Abstract: Synthesis and Pharmacological Activity of Hetaroylpyruvic Acids and Their Derivatives.

✍ Scribed by T. N. YANBORISOV; I. A. ZHIKINA; YU. S. ANDREICHIKOV; A. V. MILYUTIN; A. N. PLAKSINA

Publisher
John Wiley and Sons
Year
2010
Weight
32 KB
Volume
30
Category
Article
ISSN
0931-7597

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✦ Synopsis

Synthesis and Pharmacological Activity of Hetaroylpyruvic Acids and Their Derivatives.

-Claisen condensation of acetylheterocycles (I) with diethyl oxalate (II) affords hetaroylpyruvic acids (III) which contain a fully enolized Ξ±-carbonyl group. On reaction with hydrazines, they undergo cyclocondensation to hetarylpyrazoles (IV) and (VI). Pyruvic acids and hetarylpyrazoles possess weak antimicrobial activity. Additionally, the corresponding sodium hetaroylpyruvates show antiaggregating activity, while an antiinflammatory effect is observed for pyrazoles (IVb) and (VIb). -(YANBORISOV, T. N.;

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