ChemInform Abstract: Reactions of Aroylpyruvic Acids and Their Derivatives with o-Aminophenyldiphenylmethanol in the Synthesis of Pharmacologically Active Compounds.

✍ Scribed by N. V. KOLOTOVA; V. O. KOZ'MINYKH; E. V. DOLBILKINA; E. H. KOZ'MINYKH; V. E. KOLLA; S. A. SHELENKOVA

• Publisher: John Wiley and Sons
• Year: 2010
• Weight: 31 KB
• Volume: 30
• Category: Article
• ISSN: 0931-7597
• DOI: 10.1002/chin.199905100

✦ Synopsis

1999 triphenylmethane derivatives triphenylmethane derivatives (tetraphenylmethane derivatives) Q 0730

05 -100

Reactions of Aroylpyruvic Acids and Their Derivatives with o-Aminophenyldiphenylmethanol in the Synthesis of Pharmacologically Active Compounds.

-Reactions of aroylpyruvic acids and their esters (I) with the title aminophenylmethanol (II) under mild conditions affords the 2-arylamino-4-aryl-4-oxobutenoic acids (III) which under the action of acetic anhydride furnish benzoxazepines (V). In contrast, cyclic analogues of aroylpyruvic acids, the furandiones (VI), react with compounds (II) with furan ring opening to give arylamides (VII) which cyclize to benzoxazines (VIII). Among the prepared compounds, antiinflammatory (VII), antimicobial (III) and (VIII), or analgesic agents (VII) are observed. -(KOLOTOVA, N. V.;