ChemInform Abstract: Synthesis and Lipase-Catalyzed Acetylation of N-[(2-Alkoxycarbonyl)benzoyl]-4-hydroxyisoxazolidines.
β Scribed by Ewa Buchalska; Jan Plenkiewicz
- Publisher
- John Wiley and Sons
- Year
- 2010
- Weight
- 32 KB
- Volume
- 31
- Category
- Article
- ISSN
- 0931-7597
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Synthesis of (+)-(R)-1-Amino-2,2-difluorocyclopropane-1-carboxylic Acid Through Lipase-Catalyzed Asymmetric Acetylation. -Hydrochloride (VIII) of the title compound is prepared via the asymmetric acetylation of diol (III) as the key step. Several enzymes and conditions are investigated to obtain th