โ Scribed by P. MURUGAN; P. SHANMUGASUNDARAM; V. T. RAMAKRISHNAN; B. VENKATACHALAPATHY; N. SRIVIDYA; P. RAMAMURTHY; K. GUNASEKARAN; D. VELMURUGAN
No coin nor oath required. For personal study only.
Fifteen title compounds, e.g. (I)-(III), are prepared essentially as described previously. Evaluation of their absorption, emission and laser properties shows that N-allyl substituted derivatives (Ia) and (IIa) have high fluorescence quantum yields and laser efficiencies of 137 and 140%, respectively. X-ray crystal analysis of compound (Ib) shows that it is folded about the line passing through C-9 and N-10 and that the methyl group at C-9 is in equatorial position.
๐ SIMILAR VOLUMES
In order to prepare new tacrine-like compounds, the title compounds (VII), (X) and (XV) are synthesized. The synthetic pathway to (VII) represents a shorter and more suitable approach to prepare tacrine metabolites. An alternative route from (VIb) to compound (VIII), which exhibits very strong DNA b