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ChemInform Abstract: Synthesis and in vitro Evaluation of Novel Morpholinyl- and Methylpiperazinylacyloxyalkyl Prodrugs of 2-(6-Methoxy-2-naphthyl)propionic Acid (Naproxen) for Topical Drug Delivery.

✍ Scribed by Jarkko Rautio; Tapio Nevalainen; Hannu Taipale; Jouko Vepsaelaeinen; Jukka Gynther; Krista Laine; Tomi Jaervinen


Publisher
John Wiley and Sons
Year
2010
Weight
28 KB
Volume
31
Category
Article
ISSN
0931-7597

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ATP-Citrate Lyase as a Target for Hypolipidemic Intervention. Part 2. Synthesis and Evaluation of (3R\*,5S\*)-Ο‰-Substituted-3carboxy-3,5-dihydroxyalkanoic Acids and Their Ξ³-Lactone Prodrugs as Inhibitors of the Enzyme in vitro and in vivo. -A series of the title compounds is synthesized and evalua