ChemInform Abstract: Synthesis and Enzymatic Cyclization of (3S)11-Fluoro-2,3-oxidosqualene.
β Scribed by B. ROBUSTELL; I. ABE; G. D. PRESTWICH
- Publisher
- John Wiley and Sons
- Year
- 2010
- Weight
- 41 KB
- Volume
- 29
- Category
- Article
- ISSN
- 0931-7597
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A convergent asymmetric synthesis led to (3S)-14-fluoro-2,3-oxidosqualene (14-FOS, 16), which was cyclized by bacterial squalene:hopane cyclase to a monocarbocyclic product with a bridged ether and a 2:3 mixture of bicyclic alcohols. 14-FOS was neither a substrate nor an inhibitor for vertebrate oxi
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