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ChemInform Abstract: Synthesis and Dopaminergic Properties of 3- and 4-Substituted 1-(2-(5-( 1H-Benzimidazole-2-thione))ethyl)piperidines and Related Compounds.

✍ Scribed by S. DUKIC; S. KOSTIC-RAJACIC; V. SOSKIC; J. JOKSIMOVIC

Publisher: John Wiley and Sons
Year: 2010
Weight: 29 KB
Volume: 28
Category: Article
ISSN: 0931-7597
DOI: 10.1002/chin.199729251

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✦ Synopsis

Synthesis and Dopaminergic Properties of 3-and 4-Substituted 1-(2-(5-( 1H-Benzimidazole-2-thione))ethyl)piperidines and Related Compounds.

-Among a series of title compounds, e.g. (I), especially compound (Ia) and its (+)-enantiomer behave as selective high affinity D2 receptor ligands. Only some of the tested products, e.g. (Ic), express moderate affinity for the D1 receptor. -(

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