Synthesis and Diuretic Activity of 2,3-Dihydro-4(1H)-quinolinone 4-Oxime-O-sulfonic Acid Derivatives. -On the basis of the known compound M12285, different types of derivatives such as (IV), (VIII), and (XIII) are prepared. The most promising compound (VIII) (M17055) is the best for development of
ChemInform Abstract: Synthesis and Diuretic Activity of 4,5-Dihydro-6H-imidazo[4,5,1-ij]quinoline-6-one 6-Oxime-O-sulfonic Acid Derivatives.
โ Scribed by Kazumi Nishijima; Tomoaki Shinkawa; Manabu Ito; Hidemitsu Nishida; Ichirou Yamamoto; Yoshiaki Onuki; Hitoshi Inaba; Soutarou Miyano
- Publisher
- John Wiley and Sons
- Year
- 2010
- Weight
- 29 KB
- Volume
- 30
- Category
- Article
- ISSN
- 0931-7597
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โฆ Synopsis
Synthesis and Diuretic Activity of 4,5-Dihydro-6H-imidazo[4,5,1ij]quinoline-6-one 6-Oxime-O-sulfonic Acid Derivatives.
-Among a variety of prepared title compounds, e.g. (I), (II), and (III), derivatives (I) show diuretic activity comparable, cf. (Ia) and (Ib), or superior, cf. (Ic), to that of M17055.
-(NISHIJIMA, KAZUMI; SHINKAWA, TOMOAKI;
๐ SIMILAR VOLUMES
Synthesis and Reactions of 4H-Imidazo(4,5-e)(2,1,3)benzothiadiazol-5( 6H)-one. -The condensation of the diamino benzothiadiazole (I) with urea provides the imidazo derivative (III). Some reactions such as oximation and dialkylation are investigated. Corresponding monosubstituted derivatives of type