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ChemInform Abstract: Synthesis and Diuretic Activity of 2,3-Dihydro-4(1H)-quinolinone 4-Oxime-O-sulfonic Acid Derivatives.

✍ Scribed by K. NISHIJIMA; T. SHINKAWA; Y. YAMASHITA; N. SATO; H. NISHIDA; K. KATO; Y. ONUKI; M. MIZOTA; K. OHTOMO; S. MIYANO

Publisher
John Wiley and Sons
Year
2010
Weight
36 KB
Volume
29
Category
Article
ISSN
0931-7597

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✦ Synopsis

Synthesis and Diuretic Activity of 2,3-Dihydro-4(1H)-quinolinone 4-Oxime-O-sulfonic Acid Derivatives.

-On the basis of the known compound M12285, different types of derivatives such as (IV), (VIII), and (XIII) are prepared. The most promising compound (VIII) (M17055) is the best for development of diuretic activity and is chosen for a more detailed pharmacological characterization.

-(NISHIJIMA, K.; SHINKAWA, T.;

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