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ChemInform Abstract: Synthesis and Cytotoxicity of 4-Amino-5-oxopyrido[2,3-d]pyrimidine Nucleosides.

✍ Scribed by Jean-Luc Girardet; Esmir Gunic; Cathey Esler; Dariusz Cieslak; Zbigniew Pietrzkowski; Guangyi Wang


Publisher
John Wiley and Sons
Year
2001
Weight
31 KB
Volume
32
Category
Article
ISSN
0931-7597

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Synthesis of 1,2,3-Thiadiazolo (5,4-d)pyrimidines. -Condensation of 5-aminothiadiazole-4-carboxamides (I) or (IV) with orthoesters provides the target thiadiazolopyrimidines in moderate to good yield. Attempts to synthesize this heterocyclic system by three-component condensation of readily availab