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ChemInform Abstract: Synthesis and Cytotoxicity of 2-Methyl-4,9-dihydro-1-substituted-1H-imidazo [4,5-g]quinoxaline-4,9-diones and 2,3-Disubstituted-5,10-pyrazino[2,3-g]quinoxalinediones.

✍ Scribed by Hee-Won Yoo; Myung-Eun Suh; Sang Woo Park

Publisher
John Wiley and Sons
Year
2010
Weight
29 KB
Volume
30
Category
Article
ISSN
0931-7597

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✦ Synopsis

Synthesis and Cytotoxicity of 2-Methyl-4,9-dihydro-1-substituted-1H-imidazo [4,5-g]quinoxaline-4,9-diones and 2,3-Disubstituted-5,10pyrazino[2,3-g]quinoxalinediones.

-Among a series of quinoxaline derivatives, derivative (Id) shows more potent cytotoxicity against human gastric adenocarcinoma cells (MKN 45) than reference compounds adriamycin and cis-platin. Derivative (IIc) shows in vitro cytotoxicity comparable to adriamycin and 10 times higher than that of cis-platin. Since both compounds are less active on human lung and colon adenocarcinoma cells, especially imidazoquinoxalinedione (Id) might be an excellent and selective antitumor agent against MKN 45. -(YOO, HEE-WON; SUH, MYUNG-EUN; PARK,

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